It has been consistently ranked, by a number of publications, as one of the top high schools in the United States.

It offered both morning and afternoon classes and allowed motivated high school students to enroll in higher-level courses.

In particular, the Accelerated, Compacted, Enriched Program (ACE) was developed for freshmen and sophomores who seek advanced English, foreign language, math, and science offerings.

All students are required to perform more than 100 hours of service to their school, local, and global communities.

[12] Signature School is located in several buildings in downtown Evansville, Indiana on the Main Street walkway.

These include the fourth floor of the Victory Theatre; the Robert L. Koch II Science Building, which is attached to the Gerling Law Firm offices; the YMCA (for PE classes); and the Browning Rooms at Central Library.

In 2015, Signature School received $2.5 million in funding for the building of the new science center as part of the Regional Cities Initiative.