Signature has presented entire seasons of the work of Edward Albee, Lee Blessing, David Henry Hwang, Horton Foote, María Irene Fornés, Athol Fugard, John Guare, Bill Irwin, Adrienne Kennedy, Romulus Linney, Charles Mee, Arthur Miller, Sam Shepard, Paula Vogel, August Wilson, Lanford Wilson, A. R. Gurney, Naomi Wallace and a season celebrating the historic Negro Ensemble Company.
In honor of its 20th anniversary, Signature launched a subsidized ticketing initiative designed to improve Off Broadway accessibility.
[5] James Houghton founded the theatre in a black box theater at 31 Bond Street in the NoHo neighborhood in 1991 at the Kampo Cultural Center (a venue that had focused on promoting Japanese calligraphy).
[6] Their lease at this location was scheduled to expire at the end of 2011, and the company began a search for a long term home.
[7] In October 2008, Signature announced the creation of the Pershing Square Signature Center, a block east of their former home, which opened in 2012 and was designed by Frank Gehry Architects, the architect's first project for a theatre company.