Signe Kallesøe Bruun (born 6 April 1998) is a Danish professional footballer who plays as a striker for Liga F club Real Madrid and the Denmark national team.

[4] On 8 November 2014, Bruun made her UEFA Women's Champions League debut as a 74th minute substitute for Nadia Nadim in a 2–1 round of 16 defeat to Swedish team FC Rosengård.

[7] She made her competitive comeback in the delayed Coupe de France semi-final on 2 August 2020, scoring an 84th minute winner in a 2–1 win against Bordeaux.

[12] On 27 January 2022, Bruun made a deadline day move to English FA Women's Super League club Manchester United on loan for the remainder of the 2021–22 season.

On 24 October 2017, Bruun debuted for the senior Denmark national team in a 2019 FIFA Women's World Cup qualifier against Croatia.