Starring Josh Zuckerman, Nathaniel Buzolic and Krista Allen, it premiered on The CW network on August 3 and ended its run on October 5, 2015.

[2] Restaurateur Nate Marlowe (Zuckerman) is shocked to discover that his best friend and roommate, Jimmy Barnes (Buzolic), has had sex with his mother, Lydia (Allen).

Nate and his father Harrison (Jonathan Silverman) find that they must face the reality that Lydia and Jimmy plan to pursue their relationship.

Significant Mother was ordered to series for the CW on April 10, 2015, with Zuckerman and Allen attached to star and Silverman, Fitzpatrick and Adams rounding out the cast.

[6][7] In June 2015, the CW announced guest stars Linda Gray as Gammy, Nate's grandmother and Lydia's conservative southern mother,[8] and Jerry O'Connell as Bob Babcock, a "slick realtor".