Married, he is the father of four boys (Taavi Kalle, Heiki Rein, Mati Kalev, Arti Tanel) and a girl (Mari Helmi).

He was re-elected to the Riigikogu on 4 March 2007, and named Vice-Minister of Economic Affairs and Communications, under Juhan Parts.

On 23 January 2008, Siim-Valmar Kiisler became Minister of Regional Affairs in the second cabinet of Andrus Ansip.

On 12 June 2017, he was appointed Minister of the Environment in Ratas' first cabinet as the successor to Marko Pomerants.

[1] It was only through the death of his party colleague Mart Nutt that Kiisler returned to the government in June 2019.