There are two villages, "Allopronia" on the south sea side, being the port, and another higher up in the hills being the chora.

The chora up on the hills is composed of two settlements adjacent to each other, "Castro" to the west and "Chorio" to the east.

[4][5][6] It is said to have been originally called Oenoë from its cultivation of the vine, but to have been named Sicinos after a son of Thoas and Oenoe.

Like most of the other Grecian islands, it submitted to Xerxes I in the Greco-Persian Wars,[8] but it afterwards formed part of the Athenian maritime empire.

There is also still extant an ancient temple of the Pythian Apollo, now converted into the church Episkopí (ἡ Ἐπισκοπή).

[10] In 2022, the Ephorate of Antiquities of the Cyclades was granted the Europa Nostra Award for its work excavating and restoring the monument, now considered a Roman mausoleum and later Byzantine church.