Silke Möller (née Gladisch, born 20 June 1964) is a German athlete, who in the 1980s competed for East Germany as one of the best female sprinters in the world.

She and teammates Sabine Rieger, Marlies Göhr, and Ingrid Auerswald ran a time of 41.37 seconds, which stood as the world record until 2012.

At the 1988 Summer Olympics in Seoul she won the silver medal as a member of the East German 4 × 100 m relay team (she had at that time taken the name Möller).

In 1992 she was implicated with Katrin Krabbe and Grit Breuer in a doping scandal, but was later cleared by the International Athletic Federation (IAAF).

Möller represented the Empor Rostock sport club and trained under Wolfgang Meier (Marita Koch's coach and now husband).