Simeon Brewster Chase (April 18, 1828 – January 9, 1909) was an American politician who served in the Pennsylvania House of Representatives and was active in the Prohibition Party.

[1] Simeon Brewster Chase was born on April 18, 1828, to Amasa Chase and Sarah Guile in Gibson, Pennsylvania.

In 1851, he graduated from Hamilton College with a law degree and later married Fanny DuBois.

In 1851, he and Ezra Chase, who later served as the Speaker of the Pennsylvania House of Representatives, purchase the Montrose Democrat and served as an editor for the paper until he left the Democratic Party in 1856 to join the Republican.

[4] In 1872, he received the Prohibition gubernatorial nomination, ran for Pennsylvania Supreme Court in 1878, and ran for the House of Representatives in 1878, 1886, 1888, and 1892.