[5] Therefore, on Sunday 17 March 1647 he was consecrated bishop in the Venetian church of Santa Maria Gloriosa dei Frari by the Nuncio in Venice, Scipione Pannocchieschi d'Elci.
[3] In Nin Simeone Difnico started to restore the Cathedral and to tried to settle a conflict about tithes with the near Diocese of Zadar.
His episcopate occurred during the first phase of the Cretan War (1645–1669) which was fought also in Dalmatia: the town of Nin was destroyed in 1647 and the population evacuated in the near Zadar, where Simeone succeeded in securing the furnishings and liturgical books.
[6] His main conflicts were however against the local feudatories, who no more recognized the Bishop as own Lord, refusing to pay to the Church the tithe and on the contrary imposing their taxes.
[4] This conflict had a negative impact on the local population: for example, in the argument about who had the right to appoint the parish priest of Strigno, Simone Difnico launched the interdict on that little town, and so no religious ceremonies were there celebrated from 6 January 1650 to 13 February 1652.