Simferopol Raion (Ukrainian: Сімферопольський район, Russian: Симферопольский район, Crimean Tatar: Aqmescit rayonı) is one of the 25 regions of the Crimean peninsula, administered by Russia, but considered by many countries as part of Ukraine.

The administrative center of the raion is the city of Simferopol which is incorporated as a town of republican significance and is not a part of the district.

The Simferopol Raion is situated in the central part of the peninsula.

In July 2020, Ukraine conducted an administrative reform throughout its de jure territory.

This included Crimea, which was at the time occupied by Russia, and is still ongoing as of October 2023.