A figure of importance in the Junimea literary club, he was for a while editor of its magazine, Convorbiri Literare, and became a supporter of the fascist Iron Guard.
He then pursued his studies in Paris, with Paul Vidal de la Blache, and at the University of Berlin, with Ferdinand von Richthofen.
In 1895, Mehedinți transferred to Leipzig University, where he completed a Ph.D. degree in early 1899, with thesis "Über die Kartographische Induction" written under the direction of Friedrich Ratzel.
[3] He was a strong proponent of the geomorphology approach to geographic studies; his powerful position enabled him to impose this point of view on Romanian geography.
Streets in Oradea, Otopeni, Sibiu, and in the Crângași neighborhood of Bucharest are named after him.