Educated at Bolton School, Holt immersed himself in organ, piano and visual art during his sixth form years.
Shortly before achieving a diploma in composition from the Royal Northern College of Music, where he studied with Anthony Gilbert for four years from 1978 to 1982, he received a commission from the London Sinfonietta, which became Kites (1983).
He was soon firmly established with a series of commissions and fruitful collaborations including not only with the Sinfonietta, but also the Nash Ensemble and the Birmingham Contemporary Music Group, resulting in pieces such as eco-pavan (1998), Sparrow Night (1989) and Lilith (1990) respectively.
Inspired by Messiaen, Xenakis and Feldman as well as visual artists such as Goya, Alberto Giacometti and Brâncuși, his music is innately dramatic and impulsive in nature.
Recent commissions include the orchestral piece, Surcos (2016), for Sir Simon Rattle and the Berliner Philharmoniker and co-commissioned by the City of Birmingham Symphony Orchestra who gave the UK premiere with the conductor Ilan Volkov and the basset clarinet concerto, Joy Beast (2016), for Mark Simpson and the BBC Philharmonic as part of the New Music Biennial 2017.