Simon Mayo Drivetime, is the incarnation of the drivetime show on BBC Radio 2 between 11 January 2010 and 4 May 2018, being revived briefly for Mayo's final show with the station on 21 December that year, and then fully from 15 March 2021 on Greatest Hits Radio.

They presented their last show together on 20 December, with Mayo hosting solo the following day, marking the end of his 17-year stint at the station.

He also announced the weekly rock tune on Wednesdays as "Doctor Mosh",[4] as well as participating in the daily confessions as 'Brother Matt'.

Alan Dedicoat was the regular newsreader and continuity announcer on BBC Radio 2, who read the 17:00 news occasionally, coming into the show.

Rebecca Pike presented the business news at 17:30 and 18:40 every day, and at the end of the 17:30 bulletin also reports on the FTSE market data and exchange rates.

Current producer Suzi Purdie joins in with the show every day, joining in with the Drivetime Drama and taking part in the daily Confessions as 'Sister Suzi' Assistant Producer Holly Carnegie joins in with the show every day, joining in with the Drivetime Drama and taking part in the daily Confessions as 'Sister Holly' Stand-in presenters on the Radio 2 incarnation of the show included Patrick Kielty, Liza Tarbuck, Ryan Tubridy, Richard Allinson, Richard Bacon, Mark Goodier, Sara Cox and Amol Rajan, stand-in hosts on the Greatest Hits Radio version of the show are Richard Allinson, Jackie Brambles, Kate Thornton, Andy Crane, Alex Lester, and Mark Goodier.

The show's opening and closing theme tune is a 2003 recording by Jools Holland and Prince Buster of the 1948 song "Enjoy Yourself (It's Later than You Think)" by Carl Sigman and Herb Magidson.

Regular background music used on Fridays included "On the Rebound" by Floyd Cramer, "Tom Hark" by The Piranhas, "A Swingin' Safari" by Bert Kaempfert, "Giorgio by Moroder" by Daft Punk, "House of the King" by Focus, and “Never Going Back Again” by Fleetwood Mac as well as other stock instrumentals in different musical styles.

Such events included pre-show coverage of the BBC Radio 2 Folk Awards, a fortnight of special shows for the London 2012 Olympics and a special programme from the Science Museum in London to commemorate the BBC's 90th anniversary on 14 November 2012.