Son of Raynaud Vigor, a court physician, he went to Paris about 1520, where his studies included Greek, Hebrew, and Latin; later he devoted himself to theology.
On his return to France, Vigor became pastor of the Church of St. Paul-de-Paris, the royal parish, theologian of the chapter of Notre-Dame de Paris, and court preacher.
According to Génébrard the defeat of the ministers was so overwhelming that the subsequent Calvinist synod forbade conferences to be held thenceforth with Catholics.
He never returned to Paris or to his home, being wholly engaged in converting the Protestants of his own and the neighbouring dioceses, in which work death overtook him.
After his death the Bishop of Rennes in a letter to Gregory XIII called him the Athanasius or Hilary of his time, and Duval praised him as a model of learning and piety, a pillar of the Roman Church.