Ventura's career continued on Mediaset channels hosting variety shows like "Mai dire gol", "Cuori e Denari, "Boom", "Scherzi a parte" (a programme very similar to Punk'd), "Festivalbar", "Le Iene", "Matricole", Gli indelebili '99, "Cari amici miei", "Zelig - Noi facciamo cabaret", and "Piccole Canaglie".

In 2005 and 2006 she presented Music farm, a show similar to the Hit Me, Baby, One More Time format, on Rai Due.

In early 2016 Simona Ventura returned to Mediaset as a contestant in the XI season of the popular reality show L'isola dei famosi now hosted by Alessia Marcuzzi with Alvin on Canale 5 and won by Giacobbe Fragomeni.

In the autumn of 2016[1] Mariano Di Vaio (in couple[2] with the dancer Stefano De Martino) is one of the tutors/mentors[3] of the first season of Selfie – Le cose cambiano,[4] the new talent show produced by Fascino PGT of Maria De Filippi and aired by Canale 5 with Simona Ventura as presenter.

[5] Bernardo Corradi (in couple[6] with the dancer Stefano De Martino) in May-June 2017 is one of the tutors/mentors[6] in the second season of Selfie – Le cose cambiano, a talent show produced by Fascino PGT[7] of Maria De Filippi and aired by Canale 5 with Simona Ventura as presenter.

In 2008 Ventura starred in La fidanzata di papà with Massimo Boldi and Elisabetta Canalis.

In 2009 Ventura was trolled by English rock band Muse in her show "Quelli che.. il Calcio".