He works in Cinema, Theater and TV, with directors such as Gabriele Salvatores, Guido Chiesa, Gianpaolo Tescari, Lucio Gaudino, Carmine Elia, Vittorio Franceschi, Giovanni Pampiglione, Francesco Marino, Marina Malfatti, Lindsay Kemp, Eimuntas Nekrosius, Nicolaj Karpov, Susan Batson, Marilyn Fried, Steven Berkoff, Pierre Byland.

2008/2009: Borrelli was one of the lead actors, playing the character Mauro Morbello, in the TV series Terapia d'urgenza (produced by RAI – Radio Televisione italiana).

In 2011 Simone Borrelli played the role of Ivan in Anna e i cinque directed by Franco Amurri and produced by Magnolia for Mediaset.

In 2007, as an actor and dancer, Borrelli took part in the European tour of Sinfonia, directed by Silvia Traversi (Folkwang Hochschule di Pina Bausch e Carolyn Carlson Company).

[5] In 2014 he was the scriptwriter, director, lead actor, singer and composer of the original soundtrack of Eddy,[6] an international film about violence against children.