When Simone Deveaux is introduced in the premiere episode, she is an art dealer living in New York City who is romantically involved with artist Isaac Mendez.
Later that day, Peter Petrelli, who until recently had been a hospice nurse caring for Simone's father, confesses his love for her.
Simone is gradually starting to believe that Isaac can paint the future, and hopes Peter will come back alive.
In the episode "Fallout", Peter has a vision in which he sees all of the series' main characters in New York, seemingly running away from him.
Later, in the same episode, Simone meets with Isaac on the roof of her departed father's building and they discuss the future before going to dinner together.
In the episode "Unexpected", Simone visits Isaac, but the painter tells her that he thinks Peter might have left New York (though he is in fact aware that he is still somewhere in the city).
Later, Simone confronts Nathan, telling him to reveal Peter's condition as well as the powers of others, in order to get help.
After Peter blacks out in an empty street, he has a dream of the past, awakening on the Deveaux building's rooftop.
[1] The writers had discussed several storyline possibilities for Simone such as pregnancy and becoming another "Horn Rimmed Glasses" (Noah Bennet).
[2] It feels appropriate to die at the hands of my two suitors, (...) All of the deaths on Heroes so far have been very ugly and graphic, and this one was more [like] a beautiful fade-away.