[4][5] Inzaghi began his playing career in 1994 with Piacenza but was loaned to several clubs, including Novara and Lumezzane, where he won back-to-back Serie C2 titles in 1996 and 1997.

[6] Inzaghi began his senior coaching career with Lazio in 2016, after previously being in charge of the club's youth teams from 2010, and won one Coppa Italia and two Supercoppa Italiana titles.

Despite stiff competition within a Lazio side packed with quality strikers such as Marcelo Salas and Alen Bokšić, the rotation policy of manager Sven-Göran Eriksson ensured that Inzaghi would get playing time; he appeared in 22 out of 34 Serie A matches in Lazio's highly successful 1999–2000 season scoring seven goals, as his team went on to complete the domestic Double by winning both the Scudetto and the Coppa Italia.

[7] The following seasons were not as successful, but Inzaghi did help Lazio conquer another Coppa Italia, in 2003–04; in September of that year, he extended his contract until June 2009.

Although he was not particularly skilful from a technical standpoint, he was a tall and fast striker with a slender physique, who was mainly known for his eye for goal, ability to play on the edge of the offside trap and clinical finishing inside the penalty area, in particular from close range, due to his opportunism and positional sense.

[22][23] He guided the team to fifth place in the domestic league as well as the final of the Italian Cup, lost to Juventus; on 7 June 2017, he renewed his contract until 2020.

[26] The 2018–19 season saw the side win the domestic cup 2–0 over Atalanta, conquering their seventh title overall and automatically qualifying for the group stage of the UEFA Europa League.

[31] In his first season as Inter manager, Inzaghi won the Supercoppa Italiana on 12 January 2022 and the Coppa Italia on 11 May 2022, defeating Juventus at the end of extra-time in both cases, respectively 2–1 at San Siro and 4–2 at Stadio Olimpico.

[32][33] He finished the Serie A championship in second place, being the most prolific attacking side with 84 goals,[34] and the Champions League campaign in the round of sixteen, being eliminated by Liverpool with a 1–2 on aggregate (2–0 defeat at San Siro and 1–0 win at Anfield).

But, perhaps his most notable achievement was getting Inter into the Champions League Final for the first time in 13 years, after a memorable knock-out stage run which included a 3–0 aggregate victory over local rivals A.C. Milan in the semi-finals.

[38] On 15 January 2024, Inzaghi placed third in the 2023 Best FIFA Men's Coach award, behind winner Pep Guardiola and compatriot Luciano Spalletti.

[42][43] In 2022, Francesco Porzio of CBS Soccer noted that Inzaghi gave his players more freedom tactically than his predecessor Antonio Conte, which had a positive impact on the team's performances.

While Simone scored the opening goal from the penalty spot in the 3–0 historic win against Reggina, Filippo failed to make a difference in Perugia as Juventus lost the title race at its finish.