Simone Niggli-Luder (born 9 January 1978) is a Swiss orienteering athlete who has twice won (in 2003 and 2005) all four women's competitions at the world championships.

[citation needed] She began competing in orienteering early on, joining the Swiss club OLV Hindelbank; at the age of ten, she participated in her first competition.

[citation needed] In 2003, she won all four women's competitions of the world championships held at Rapperswil in Switzerland (sprint, middle, and long distance, and— together with Birgitte Wolf and Vroni König-Salmi— the relay).

At the World Championships 2013 at Vuokatti, Finland, she won all three single competitions (sprint, middle, and long distance) and finished third in the team relay event (together with Sara Luescher and Judith Wyder).

In September 2013, Niggli-Luder announced that she was retiring from elite orienteering at the end of the year, after the last World Cup race in New Zealand.