He is known for his work with the Sanremo Festival Orchestra,[1][2]Chicanery, Billy Sheehan, Aaron Carter, Disney, Hannah Montana, Vasco Rossi, Amber Lily, and Warren Cuccurullo, both as a producer and guitarist; and as a journalist for the magazines Chitarre, Strumenti Musicali, Accordo and Ganzo.

His influences include major classical and jazz composers and performers, (Bach, Ravel, Miles Davis, Weather Report), pop and rock acts (The Beatles, David Bowie, Pink Floyd, Metallica, Lucio Battisti), and experimental artists (Luciano Berio, Brian Eno, Terje Rypdal, Klaus Schulze).

[4] Then, he got hired to play with Italian pop singers Renato Zero, Tullio De Piscopo, Nino Buonocore and Michele Zarrillo, and in several national TV shows.

From 1994 to 1997 he joined the orchestra of the Sanremo Festival, where he had a chance to play with several international musicians, such as Ray Charles, George Benson, Pat Metheny, Michael Bolton, Celine Dion, Kenny G, Nek, and Laura Pausini.

[8] In Chitarre and Accordo, Simone Sello's articles have included interviews with, among other notable musicians, Steve Vai, Lee Ritenour, and Vasco Rossi.

[17][18] In the album Simone Sello also plays bass, guitar, violin and synths; other remarkable musicians include vocalist Neil Carlill and guest drummer Terry Bozzio.

Then he collaborated to the CDTracks II – Inediti e rarità (2009), programming the hit song Sto Pensando A Te and playing lead guitar on Ho Fatto Un Sogno; in 2011, Vasco Rossi released a new studio album Vivere O Niente, which features Simone Sello on guitar, keyboards and programing on several tracks, and includes a song he co-wrote with Vasco and Saverio Principini, called Manifesto Futurista Della Nuova Umanità.

On March 8 2024, in occasion of international women day, Vasco Rossi presented and released the song Libera e se mi va written by him for the singer Denise Faro who recorded the final version, co-produced by Simone Sello.