Simone Sini (born 9 April 1992) is an Italian footballer who plays as a centre back for Serie D club Chieti.
On 5 August 2011, he joined A.S. Bari on a long season loan deal that brought teammates Alessandro Crescenzi and Adrian Stoian to the team too.
On 31 January 2012, Sini left for Livorno in another temporary deal, with an option to sign half of the "card" for €400,000.
On 15 July 2015, Sini signed a two-year contract with Serie B club Virtus Entella.
On 10 August 2011, he made his debut with the Italy U-21 team, in a friendly match against Switzerland.