A skilled merchant, in Antwerp and in the County of Flanders, he made his fortune while maintaining economic and state relations with Genoa.

[1] Without ever neglecting his interests in Flanders where he periodically went, he received the position of ambassador to Genoa from the Senate in the papal court of Pope Pius V during 1566.

[2] Returning to the Genoese capital in 1567, Simone Spinola, on 15 October that year, was elected by the Grand Council new Doge of the Republic of Genoa, the twenty-first since the biennial reform and the sixty-sixth in republican history.

[2] The benevolent efforts that led to a reconciliation of the relations between the Genoese republic and its colony of Corsica are mentioned in the annals of the main and relevant facts of its stave.

The body was buried in the mausoleum of the chapel of Santa Caterina da Siena inside the no longer existing church of San Domenico.