[2] As one of the largest charitable organizations in the United States with assets of over $5 billion in 2022,[3] the foundation's mission is to advance the frontiers of research in mathematics and basic sciences.

[10] As of December 2018,[update] the Simons Foundation is listed as a White House BRAIN Initiative Alliance Member.

[11] The Simons Collaboration on the Global Brain (SCGB) is working to understand the internal processes underlying cognition.

[12] In May 2022, the Simons Foundation partnered with Stony Brook University to boost diversity in STEM, with a $56 million gift.

The Exchange — a $700 million, 172-acre international center for developing and deploying dynamic solutions to the global climate crisis — is set to open in 2028.