The implantable cardioverter-defibrillator (ICD) was invented here by the team of Dr. Michel Mirowski, Dr. Morton Mower, M. Stephen Heilman, and Alois Langer who are all in the National Inventors Hall of Fame for their achievement.

Since 1998, Sinai Hospital has been a part of the LifeBridge Health system,[2] which also runs Northwest Hospital in Randallstown, Carroll Hospital in Westminster, Levindale Hebrew Geriatric Center and Nursing Home (which is across the street from Sinai), Grace Medical Center in West Baltimore City, Rubin Institute for Advanced Orthopedics, several medical office buildings in the Baltimore area, and a health and fitness club called LifeBridge Health & Fitness, located in Pikesville, Maryland.

[4] The specialty areas at Sinai include: Former Baltimore Orioles star pitcher Dave McNally was admitted to the hospital in late June 1975 with a case of chronic hiccups that had plagued him for nine days.

[5] Former Baltimore Orioles outfielder Paul Blair died at this hospital in late December 2013 after collapsing at a bowling alley in nearby Pikesville, Maryland.

Beginning in the Fall of 2024, George Washington University's School of Medicine and Health Sciences has specifically matriculated 30 students in each entering class to complete their third- and fourth-year rotations at Sinai Hospital.