In 1585 the second foundation of the town was carried out by Antonio Ruiz, Bartolomé de Mondragón, Tomás de Soberanes, Juan Martínez del Castillo y Juan Caballero.

[2] By 1590, Ruiz was its mayor, and the town was home to nine people who eked out a living, but the situation improved through their discovery of the mines of Chínipas, and the arrival of the Jesuit missionaries Gonzalo de Tapia and Martín Pérez in 1591.

[3][4] At the end of the sixteenth century, Ruiz wrote an autobiography where he detailed the early history of San Felipe y Santiago, and Sinaloa.

In 1595, Luis de Velasco granted residents' petitions for a presidio at San Felipe y Santiago, and Diego Fernández de Velasco (governor) [es] dispatched Captain Alonso Díaz with 24 soldiers to found it.

[4] This was the base for Diego de Hurdaide's subjugation of the Sinaloas, Tehuecos, Ahomes and Zuaques and the extension of Spanish control over the Fuerte River valley, and thus to the northern edge of modern Sinaloa.