Sindh played its first first-class game in December 1932, when they drew with Ceylon at the Gymkhana ground in Karachi.

On 27 December 1947 Sind hosted the first first-class game to be played in Pakistan, but were defeated by an innings and 68 runs by Punjab.

The greatest Sindh player in the Ranji Trophy period was Naoomal Jeoomal who played in India's first test match against England at Lord's in 1932.

In Pakistani domestic cricket, Sindh played in the Quaid-e-Azam Trophy each season from 1953–54 to 1956–57, but then made only sporadic appearances at first-class level until the 1970s, when two Sindh teams (Sind A and Sind B) competed in the Quaid-e-Azam Trophy for several years; the province also played List A cricket.

The team was introduced as a part of the new domestic structure announced by the Pakistan Cricket Board (PCB) on 31 August 2019.