[2] However, the museum's collections had been forming for several decades before the museum was established, as members of the School of Dentistry faculty, including Dr. Charles Kelsey, Professor Al Richards, and dental librarian Sue Segar, preserved and stored equipment, photos, and documents relating to the history of dentistry and the history of the dental school.

Following two years of construction, the Sindecuse Museum reopened on September 8, 2000, with a new atrium taking the place of what was formerly a courtyard that connected the Kellogg and Dental Buildings.

[2] The museum's current staff consists of two full-time employees, a curator and a collections coordinator, and a number of part-time University of Michigan students.

[5] Artifacts date from the 18th century to the present day, and include dental equipment such as articulators, denture-forming equipment, and dental X-ray items, as well as historical oral hygiene items, which include a toothpaste and tooth powder collection on loan.

[5] The museum's collection includes "toothbrushes with heads greater than two inches in length, floss made from silk and examination chairs grand enough for a king.