Sint-Denijs-Westrem (Dutch: [ˌsɪn dəˈnɛis ˈʋɛstrəm]; French: Saint-Denis-Westrem) is a sub-municipality of the city of Ghent located in the province of East Flanders, Flemish Region, Belgium.

Archeological digs on the Flanders Expo site have shown significant signs of settlement from prehistory through the Middle Ages.

[2] During the late Middle Ages the castles of Idewalle, Borluut, Darupt, Hof ten Broecke, Maaltekasteel were built in and around the Sint-Denijs-Westrem area.

In 1858, architect, artisan and designer Jean-Baptiste Bethune moved his studio from Bruges to Sint-Denijs-Westrem.

Until the 20th century the area was mainly agrarian and sparsely populated; from the second half of the 20th century on the village has been steadily more densely built up, with many castle grounds subdivided for housing development.