From his father's second marriage, he had several half-siblings, including Cecilia Wake (who married Henry Newcome), the Rev.
His maternal grandparents were Mary (née Warneford) Sitwell and Francis Hurt of Mount Pleasant, Sheffield, who changed his surname to Sitwell in 1777, when he inherited the Renishaw Hall, Derbyshire estates of his mother's cousin.
[1] Upon the death of his father on 27 January 1846, he succeeded as the 10th Baronet Wake, of Clevedon, Somerset and Piddington, County of Northampton, in the Baronetage of England.
[1] On 23 August 1815, he married his cousin, Mary Alice Sitwell (c. 1792–1816), a daughter of his maternal uncle Sir Sitwell Sitwell, 1st Baronet and, his first wife, Alice Parke (a daughter of Thomas Parke of Highfield House, West Derby, Liverpool and sister to Baron of the Exchequer, James Parke, 1st Baron Wensleydale).
[5][6] Together, they were the parents of:[1] Sir Charles died on 23 February 1864 at age 72 and was succeeded in the baronetcy by his eldest son, William.