[3] His paternal grandparents were Sir Alexander Macdonald, 7th Baronet, and, his second wife, Lady Margaret Montgomerie (a daughter of the 9th Earl of Eglinton and Susanna Kennedy).
His maternal grandparents were Granville Leveson-Gower, 1st Marquess of Stafford and Lady Louisa Egerton (a daughter of the 1st Duke of Bridgwater).
[1] With the support of his uncle, George Leveson-Gower, 2nd Marquess of Sutherland (later first duke), Macdonald was first elected to parliament at the by-election for the Tain Burghs in 1805.
Sir James was persuaded to accept the office of Lord High Commissioner of the Ionian Islands, in the hope that the climate of the Mediterranean would improve his poor health.
[5] Before her death on 29 September 1824, they had two sons:[3] His third, and final, marriage was on 20 April 1826 to Anne Charlotte Ogle (c. 1803–1886), a daughter of the Rev.
[3] After dining at his father-in-law's home at Berkeley Square on 27 June 1832, he fell ill the next day and died of cholera on the 29th at Spring Gardens.
[6] He left the bulk of his estate including landed property, shares in the Birmingham and Liverpool Junction Co., to his only surviving son, Archibald, who succeeded him in the baronetcy.