Sir John Lyster Kaye, 4th Baronet (1697–1752) of Denby Grange, Kirkheaton, Yorkshire, was a British landowner and Tory politician who sat in the House of Commons from 1734 to 1741.
Kaye was baptised at Almondbury, on 4 September 1697, the eldest son of George Kaye of Denby Grange, Kirkheaton, Yorkshire, and his wife Dorothy Savile, daughter of Robert Savile of Bryan Royd, near Elland, Yorkshire.
He succeeded his uncle Sir Arthur Kaye, Bt to the baronetcy on 10 July 1726.
He was invited by the local Tories to stand for York at the 1734 British general election, and was returned as Member of Parliament without a contest.
In 1742, he was invited to stand again for York at a by-election, but decided not to because of his health.