Sir Justinian Isham, 4th Baronet (11 August 1658 – 13 May 1730) was an English landowner and Tory politician, who sat in the House of Commons almost continuously from 1685 until his death in 1730.
He married, on 16 July 1683, in Stoke Rochford, Lincolnshire, Elizabeth Turnor (1666-1713), the only daughter of Sir Edmund Turnor (1619-1707) of Stoke Rochford Hall in Kent, and his wife Margaret Harrison (1623-1679), the daughter of Sir John Harrison (1589-1669).
He was returned again at the second general election of 1701 and in 1702 supported the motion vindicating the Commons’ late proceedings in impeaching the Whig ministers.
At the 1705 English general election he was returned in another contest for Northamptonshire at the top of the poll, despite a lackluster campaign.
Domesticity and ill-health led to absence from Parliament, but he was able to vote against the impeachment of Dr Sacheverell in 1710.
Isham was returned unopposed for Northamptonshire again, but after the shattering blow to his domestic contentment, was in severe depression for a year.