He was the eldest son of Francis Scott, 1st Baronet of Thirlestane, Selkirkshire, and Lady Henrietta, daughter of William Kerr, 3rd Earl of Lothian, who married in 1673.
[2] He is buried in the sealed south-west section of Greyfriars Kirkyard in Edinburgh commonly called the Covenanter's Prison.
Scott contributed to Archibald Pitcairne's Selecta Poemata (1726) some lyrics and macaronic verse; in the preface to the volume his literary merits are extolled by contemporaries.
[2] A family tradition attributed to him the ballad, The Blythsome Wedding, which was also claimed for Francis Sempill, by James Paterson (1849).
Francis Scott, son of the first marriage, became the sixth Lord Napier on the death of his grandmother, who was predeceased by his mother.