It is endemic to northern California and central Oregon in the United States.

[2][3] Additionally, Neotamias siskiyou have three brown and two gray stripes on each cheek.

[3] The specific appearance of the Siskiyou chipmunk varies due to the large geographic range the species inhabits, with larger and darker members found on the coasts compared to those found further inland.

[6] Neotamias siskiyou belongs to the Townsend group of chipmunks, which are a group of closely related chipmunk species inhabiting the western United States and Canada.

[2][7] This group of chipmunks was originally thought to be members of a single species.