He began his studies in Cambodia, before being sent to France, in Grasse then in Nice, from 1927, under the control of the Governor of Indochina, François Marius Baudoin.

The year after, the prince went back to France,[3] where he eventually entered the prestigious academy of École spéciale militaire de Saint-Cyr-Coëtquidan.

After his father's death on 23 April 1941, his nephew, King Norodom Sihanouk, nominated him as "Preah Ang Krom Luong" on 2 May 1941.

He was appointed Royal Delegate for Health, Sports and Economy and in 1946,[6] he was designated Minister of National Education in the government[7] led by his eldest brother, Prince Samdech Krom Preah Sisowath Monireth.

In 1955, after the abdication of Norodom Sihanouk and the nomination of King Norodom Suramarit and of Her Majesty Samdech Preah Mahaksatriyani Queen Sisowath Kosamak Nearirâth Serey Vatthana, his elder sister, prince Sisowath Monipong was appointed Ambassador of Cambodia in Paris,[9] where he died of a heart attack on 31 August 1956.