Sissonne (French pronunciation: [sisɔn]) is a commune in the Aisne department in Hauts-de-France in northern France.

It is about 20 km east of Laon, close to the source of the river Souche.

The community dates back to the 12th century with the first church built c.1107.

The sculptor and engraver Guillaume Dupré was born at Sissonne c.1576.

The politician Nicolas Fricoteaux was born at Sissonne in 1962.