The film centers on adult sisters Kate, an irresponsible single mother, and Maura, a kindhearted nurse and recent divorcee, who are summoned back to their childhood home by their parents to clean out their bedroom before the house is sold.

Maura Ellis, a recently divorced, hardworking nurse, is asked by her parents Deana and Bucky to return to her childhood Orlando home and clean out her bedroom before the house is sold.

Kate forces Maura to ask James, a man they hit on earlier, to come to their party and reluctantly agrees to remain sober.

Kate and Maura give a speech to their guests and ask their friend Dave to invite his drug dealer Pazuzu.

Kate learns that her parents have decided to give her a portion of the proceeds from the sale of the house to allow her to attempt a fresh start.

She calls the police with a fake noise complaint, but the responding officer recalls that Maura was kind to his disabled cousin years ago and declines to shut down the party.

The next morning, Deana and Bucky refuse Maura's offer to help pay for the damages, but reluctantly allow Kate to stay for two weeks while she and James begin home repairs.

[7] On June 12, Greta Lee was added to the cast to play Hae Won, a nail stylist who gets a pity invite to the party.

[10][11] On July 1, wrestler John Cena was added to the cast of the film, with Deadline reporting that he would play a villainous role.

[12] On July 16, Renée Elise Goldsberry was added to the cast to play Kim, a longtime friend of Poehler and Fey's characters.

[13] Principal photography commenced on June 9, 2014 in White Plains, New York when director Moore tweeted some photos from the set.

[4][3] In North America, Sisters opened on December 18, 2015 with box office projections expected to be hurt by Star Wars: The Force Awakens.

The website's critical consensus reads, "Sisters' sharp blend of pathos and vulgarity, along with Tina Fey and Amy Poehler's effervescent chemistry, are more than enough to make up for the handful of laughs this coming-of-age comedy leaves on the table.

Such is the magic of Tina Fey and Amy Poehler, the dynamic duo at the playful, prurient, occasionally perverse heart of Sisters.

[27][28] Mark Olsen of the Los Angeles Times had a more mixed reaction, saying, "There is so much about its package – the stars, the premise, the talented supporting cast – that would make for a film of warmth, humor and insight on the struggles of leaving the past behind and getting out of your own way on the path to fulfilment.