[1] The album was primarily handled by Taiwanese producer Chang Yu-sheng, with the assistance of Yu Guangyan, Ma Yu-fen, Baby Chung, David Wu, and Chen Fu-ming.

[7] In 1992, A-Mei headed on a bus to Taipei and participated in the televised "Five Lights Singing Contest" on TTV Main Channel after encouragement from her father.

After her father's death, A-Mei struggled to recall her passion for music until 1995 when she started singing in local pubs with a rock band called "Relax" which was formed by her musician cousin.

[11][12] In November 1996, A-Mei was invited to sing "I'm a Dreamer on Air," the theme song for Taiwan's UFO Radio station, which further increased her popularity.

Formerly planned to be on Pan's album "It's Time to Wake Up (該醒了)," it was delayed due to the acquisition of UFO Records by Warner Music.

[17] The guitar-driven pop ballad "Release" was composed by Jonathan Koh and written by Daryl Yao;[15] lyrically it talks about finding a new direction and moving forward after a difficult romantic breakup.

[15] Musically, it is a Latin soul-influenced power ballad that describes the feeling of emotional scars in a relationship which also features drums, guitars, and digital synthesizers.

[15] "I'm a Dreamer on Air" was also composed by Chen Chih-yuan with lyrics handled by Andy Yang[15] and musically is a mellow easy listening ballad.

[29][30] The commercial performance of Sisters surprised Forward Music, since they had low expectations for it, and even forgot to sign her up for the 8th Golden Melody Awards.

[31] As a result of the album's success in the 1990s, A-Mei was noted by journalists and commentators as a trendsetter in the Greater China region, where her influence was dubbed as "sister power.

"[34] Before the release of Sisters, there were many singers with Taiwanese aboriginal ancestry in Taiwan's entertainment industry, such as Yulunana Tanivu, Shen Wen-cheng, Sammi Kao, Wan Sha Lang, Qian Bai Hui, and Gao Jin Sumei.