Sistrurus miliarius barbouri is a venomous pit viper subspecies[2] endemic to the southeastern United States.

[4] Snellings and Collins (1997) reported a specimen measuring 80.3 cm (31.6 in) in total length, but it had been in captivity for over 12 years.

[7] The type locality listed is "Royal Palm Hammock, 12 miles west of Homestead, Dade County, Florida" (USA).

In a brood of 8 from Silver Springs, Marion County, Florida, each neonate measured between 157 and 173 mm (6.2 and 6.8 in) in total length.

This single amino acid alteration gives barbourin higher binding affinity for the fibrinogen receptor glycoprotein IIb/IIIa.