The story documents the moral decline of a once esteemed suburban family, whose descent into degeneracy begins with the purchase of a small white rat.

The film's name is a direct reference to American sitcoms, which are noted for their focus on traditional family values and whimsical humour.

The patriarch (François Marthouret) of a seemingly normal nuclear family returns home one day with a small white rat.

The animal soon has an adverse effect on his wife (Évelyne Dandry) and children, influencing them into enacting their darkest, most hidden desires.

The son, Nicolas (Adrien de Van) loudly announces his homosexuality and begins throwing wild orgies, the daughter Sophie, (Marina de Van) deliberately flirts with death and practices sadomasochism on her boyfriend (Stéphane Rideau), while the mother seduces her son so she can "cure" him of his orientation.