1OWX, 1S79, 1S7A, 1YTY, 1ZH5, 2VOD, 2VON, 2VOO, 2VOP674120823ENSG00000138385ENSMUSG00000068882P05455P32067NM_003142NM_001294145NM_001110145NM_009278NM_001355265NP_001281074NP_003133NP_001103615NP_033304NP_001342194Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.

[5] La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus.

La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.

[5][6] Sjögren syndrome antigen B has been shown to interact with nucleolin.

This article on a gene on human chromosome 2 is a stub.