She made several voyages carrying emigrants from Scotland, twice to Canada and once for the Poyais scheme.

[1] On 16 May 1818 the "brig Skeene" arrived at Halifax, Nova Scotia, with 85 passengers after a voyage of 44 days from Leith.

[5] On 5 March 1822, Skeen, Wilson, master, ran into a severe gale that took out most of her bulwarks and split her sails.

[6] In 1823 the adventurer and fantasist Gregor Macgregor chartered Skene, John Wilson, master, to take 105 (or 109[7] emigrants from Leith to Poyais, the colony in Honduras that he was promoting.

[7] By the time Skene arrived at Black River, Honduras, on 29 July 1823 the survivors from the two previous ships had already been rescued and taken to Belize.