In its first issue, the contemporary president of Stichting Skepsis, astronomer Cornelis de Jager, wrote that the paper "could fulfill a useful task in explaining many seemingly miraculous things, and consequently to the clarification of the misconceptions that exist in many people's minds.

"[3] From 1988 until 2002, astronomer Marcel Hulspas [nl] was editor-in-chief, and when he was succeeded by Rob Nanninga, the magazine first appeared in colour.

In 2007, to reduce costs, increase accessibility and facilitate production and distribution, Skepter has been concentrated more and more on the Internet.

Examples include medical claims in reflexology, 9/11 conspiracy theories, tidal forces, the hype surrounding the popular book The Secret, forged doctorates from non-existent universities, the "ridiculous" verdict by an Amsterdam judge that the Vereniging tegen de Kwakzalverij could not label orthomanual therapist M. Sickesz a "quack"[4] (later overturned[7]), iridology, Bach flower remedies, ayurveda, Aqua Detox, magnet therapy applied kinesiology, bioresonance therapy, acupuncture and reiki.

Moreover, attention is given to clairvoyance, parapsychology, auras and dowsing, but also to Egyptian pyramids, aliens, crop circles and UFOs.