The Skopje Statistical Region (Macedonian: Скопски Регион; Albanian: Rajoni i Shkupit) is one of eight statistical regions of North Macedonia.

The region is located in the north of the country, bordering Kosovo.

Internally, it borders the Vardar, Polog, Northeastern, Eastern, and Southwestern statistical regions.

The region consists of the City of Skopje and the following municipalities: The current population of the Skopje Statistical Region is 607,007 citizens, according to the last population census in 2021, accounting for 33.0% of the total national population.

The region is the largest by population in North Macedonia.