KLM Cargo joined SkyTeam Cargo in September 2004, four months after the merger of Air France and KLM, which subsequently created the Air France-KLM holding company.

However, on 14 April 2008, Northwest merged with Delta Air Lines, which led to the largest airline in the world.

China Southern Airlines joined the cargo alliance by November 2010.

[citation needed] By November 2013, Aerolíneas Argentinas, one of the leading South American carriers, joined the SkyTeam Cargo Alliance adding more than 30 Latin American destinations to the global network.

[7] As of October 2024, SkyTeam Cargo has 7 active member airlines; some do not operate dedicated cargo aircraft, they offer space in the baggage compartments of their passenger aircraft only.