The channel primarily broadcasts Police procedural shows from the United States aimed at the 18–45 age group.

[1] Sky Witness's history can be traced back to 1993 when UK Living began broadcasting.

The same Sky Witness schedule, shown in both the UK and Ireland, also includes a selection of documentary programming from both the Irish Broadcasters, RTE and TV3/Virgin Media Television Ireland (the Irish broadcaster now owned by the cable TV company of the same name in Ireland, not to be confused with the earlier Flextech version of Virgin Media Television).

The selection is similar to the genres focusing on other countries equivalent agencies, also shown on Sky Witness.

An Italian version of Sky Witness called Sky Investigation launched on 1 July 2021 with programming such as The Equalizer, Unforgettable, The Blacklist, Coroner, Law & Order, Law & Order: SVU, Bull, Private Eyes, Elementary and NCIS.