She released her debut album Gorim od želje da ubijem noć in 1980, joining in on the Yugoslav new wave scene and gaining nationwide popularity.

[5] As a violinist, she continued her musical career as a member of Radio Television Belgrade Orchestra, participating in recording of about 30 albums of different genres.

[5] The B-side of the single featured a cover of Korni Grupa song "Ivo Lola", for which Milošević provided the vocals.

One of the highlights was her interpretation of Marina Tsvetaeva's poem "I Like When You Are Yearning for Me", sung in Russian on Moscow TV, in a special birthday greeting for General Secretary of the Communist Party of the Soviet Union Leonid Brezhnev.

[6] After recording the single "Baloni" ("Balloons") with Saša Subota's Orchestra, she started performing with the disco band Zdravo,[5] led by Boban Petrović, her boyfriend at the time.

[5] In 1980, Slađana Milošević released her debut album Gorim od želje da ubijem noć (I'm Burning with Desire to Kill the Night).

[6] During 1979, Milošević made a number of guest appearances: she appeared as a backing vocalist on YU Grupa album Samo napred... and Dado Topić's album Neosedlani (The Unsaddled), and recorded the song "Imam sve" ("I've Got Everything") for the National Class Category Up to 785 ccm soundtrack, composed by Zoran Simjanović.

[5] In 1983, Milošević moved to Munich, Germany, where she formed the band Neutral Design with a group of German musicians, some of them previously performing with Santana and Nina Hagen.

[5] At the 1984 Opatija Festival, Milošević won Special Award for Interpretation for the composition "Samsara", written by Dejan Tričković (formerly of the group Susret).

[5] Later during the year, Milošević shot the TV show Djevojčica u svijetu čipova (Little Girl in the World of Microchips), directed by Ademir Kenović, for Television Sarajevo.

[5] The album, entitled Alexandra Slađana Milošević & Darko Kraljić, featured Radio Television Belgrade Jazz Orchestra, Milutin Lilić Vocal Quartet, Vladimir Vitas on piano, Vojin Draškoci on double bass, Lala Kovačev on drums, Mirjana Filipović on harp and Nikola Mitrović on trumpet.

[5][6] She had won a Special Honorary Award and a Silver Cup for an overall two-part competition that included interpretation of a traditional Chinese song and her original music.

[6] In 1989, she went on a tour across China[5] and performed at the Ilija M. Kolarac Endowment in the piece Tokata (Toccata) written by Igor Gostuški (formerly of the band Duh Nibor).

[6] During the same year, she performed the experimental piece Night Brother, written by Ognjen Bodranović, at the opening of the 23rd Belgrade International Theatre Festival.

[5] During the festival, she also performed the piece Prvi obredni san (First Ritual Dream) by Vuk Kulenović, using acoustic sculptures by sculptor Vladimir Labat.

[5] In 1989, she moved to Los Angeles, where she spent the next several years, performing in clubs with the band Baby Sister, also working in a marketing agency and as stock broker.

[5] With her brother Goran Milošević (former vocalist of Generacija 5) she recorded the duet "Jednom će neko" ("Once Someone Will") for his 1996 album Da li misliš još na mene (Are You Still Thinking of Me).

[6] During the 1999 NATO bombing of Yugoslavia, Aleksandra and Goran Milošević recorded the anti-war song "Dosta suza" ("No More Tears"), which they wrote together.

[5] The video for the album opening track, "Legalize Freedom", was banned from national television as it alluded to the authoritarian regime of Slobodan Milošević.

[6] On 13 January 2000, the Serbian (Julian) New Year celebration day, Slađana Milošević appeared on the protest concert organized by Otpor!

[5] In 2010, under the pseudonym Sweety, she recorded the song "Izdaja (Ja bih da odmorim dušu)" ("Betrayal (I Would Like to Rest My Soul") with the progressive/power metal band Alogia for the various artists album Vreme brutalnih dobronamernika (Time of Brutal Well-Intentioned People).

[5] In 2002, in Los Angeles she recorded a five-episode documentary series, Muzička industrija Amerike (American Music Industry), for the Radio Television of Serbia.

[6] Milošević was a president of the Art Es Norma association and organized A Better World campaign, with the goal of raising awareness about the importance of copyright.

[5] As a part of an anti-piracy campaign, she composed the song "Osma i deveta zapovest" ("Eight and Ninth Commandment"), co-writing the lyrics with alternative rock musician Rambo Amadeus and rapper Voodoo Popeye.