A physical player considered strong in the air, he impressed at Partizan, before spending seven seasons in La Liga at the service of three clubs, appearing in 208 matches and scoring 31 goals, mainly for Tenerife.

During his two-year spell, he partnered compatriots Janko Janković, Nikola Jerkan and Robert Prosinečki and, subsequently, he joined fellow La Liga club Tenerife for the 1995-96 season, being instrumental in their domestic and European consolidation.

[5] In the summer 1999, Jokanović signed for Deportivo La Coruña at the insistence of coach Javier Irureta, who deployed him in a partnership with Brazilians Donato and Mauro Silva.

The match was played just two days before the announcement of United Nations Security Council Resolution 757 which forbade Yugoslavia to participate at UEFA Euro 1992.

Thus, he became the first coach in the club's history to successfully defend the title; on 5 September 2009, however, he left the post by mutual consent, bidding farewell through an open letter.

[20] On 5 May 2014, Hércules appointed Jokanović as coach until the end of the season, replacing Quique Hernández, who had been sacked with the team in last place in the Segunda División table.

[22] On 7 October 2014, Jokanović was appointed on a short-term contract at the helm of English Championship club Watford, their fourth coach in five weeks.

[27] On 25 August, he led the club to the group stage of the UEFA Champions League for the first time in eleven years, after ousting Basel on the away goals rule.

[30] He was the EFL Championship Manager of the Month for April 2018 after taking 16 points from 18, having won the same award for Watford three years earlier; his compatriot forward Aleksandar Mitrović took the players' equivalent.

[37] On 17 June 2022, Jokanović signed a contract with Russian Premier League club Dynamo Moscow for the upcoming season, with the option of two further years depending on performance.