[2] The manse, a building traditionally used a residence for clergymen, is linked to the establishment of the Congregational church in Sligo and was built around 1867.

As Sligo has long been associated with W. B. Yeats, the museum has a number of exhibits dedicated to the writer, such as a replica of his 1923 Nobel Prize in Literature and works from 1889 to 1936.

The exhibitions feature some paintings from Jack Butler Yeats, George William Russell, and Seán Keating.

[2] More recently the exhibitions featured a display called News from the Past chronicling Sligo's World War I history.

The County Museum made strides in 2002 to improve upon its collection of artefacts with the purchase of furniture from the Lissadell House clearance sale.