The Slovene participating broadcaster, Radiotelevizija Slovenija (RTVSLO), held the national final Evrovizijska Melodija 2001 in order to select its entry for the contest.

Ten entries qualified to compete in the final where "Ne, ni res" performed by Nuša Derenda was selected as the winner following the combination of votes from two thematical juries and a public televote.

The broadcaster has traditionally selected its entry through a national final entitled Evrovizijska Melodija (EMA), which has been produced with variable formats.

Twenty-two songs competed in the semi-final where a public televote first selected the top six entries to proceed to the final.

Ten songs competed in the final where the winner was selected following the combination of points from two thematical juries and a public televote.

The jury groups and the televote each assigned points as follows: 1–8, 10 and 12, with the song that received the highest overall score when the votes were combined being determined the winner.

[8] The combination of points from two thematical juries (2/3) and a public televote (1/3) selected "Ne, ni res" performed Nuša Derenda as the winner.

[15] At the contest, Nuša Derenda performed the English version of "Ne, ni res", titled "Energy".